Sex ratio and age of onset in AQP4 antibody-associated NMOSD: a review and meta-analysis.

ABSTRACT:

Background

Aquaporin-4 (AQP4) antibody-associated neuromyelitis optica spectrum disorder (NMOSD) is an antibody-mediated inflammatory disease of the central nervous system. We have undertaken a systematic review and meta-analysis to ascertain the sex ratio and mean age of onset for AQP4 antibody associated NMOSD. We have also explored factors that impact on these demographic data.

Methods

A systematic search of databases was conducted according to the PRISMA guidelines. Articles reporting sex distribution and age of onset for AQP4 antibody-associated NMSOD were reviewed. An initially inclusive approach involving exploration with regression meta-analysis was followed by an analysis of just AQP4 antibody positive cases.

Results

A total of 528 articles were screened to y

SUBMITTER: Arnett S 

PROVIDER: S-EPMC11319503 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature