Geographical and temporal dynamics of genetic diversity of <i>Plasmodium falciparum</i> merozoite surface proteins 1/2 in India.

ABSTRACT: The high genetic diversity of Plasmodium falciparum (Pf) is a big obstacle to successful vaccine development programs. Here, the geographical and temporal dynamics of the genetic diversity of Indian Pf isolates from patients living in Ranchi, Raipur, Mewat, and Rourkela were analyzed. Typing and frequency of merozoite surface protein 1 and 2 genes (pfmsp1/2), their genotypes, clonality, heterozygosity, multiplicity of infection, and neutral evolution metrics were computed. A phylogenetic analysis was also performed for these two genes. The dominant allelic types were K1 (55%) and MAD20 (55%) for msp1, and FC27 (64.7%) for msp2. Infections were mainly monoclonal in Ranchi and Mewat while polyclonal in Raipur and Rourkela. Polyclonal infections dropp

SUBMITTER: Kojom Foko LP 

PROVIDER: S-EPMC11319558 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature