Optical coherence tomography quantifies gradient refractive index and mechanical stiffness gradient across the human lens.

ABSTRACT:

Background

As a key element of ocular accommodation, the inherent mechanical stiffness gradient and the gradient refractive index (GRIN) of the crystalline lens determine its deformability and optical functionality. Quantifying the GRIN profile and deformation characteristics in the lens has the potential to improve the diagnosis and follow-up of lenticular disorders and guide refractive interventions in the future.

Methods

Here, we present a type of optical coherence elastography able to examine the mechanical characteristics of the human crystalline lens and the GRIN distribution in vivo. The concept is demonstrated in a case series of 12 persons through lens displacement and strain measurements in an age-mixed group of human subjects in response to an external (ambient pr

SUBMITTER: Kling S 

PROVIDER: S-EPMC11319654 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature