Atom-pair engineering of single-atom nanozyme for boosting peroxidase-like activity.

ABSTRACT: Constructing atom-pair engineering and improving the activity of metal single-atom nanozyme (SAzyme) is significant but challenging. Herein, we design the atom-pair engineering of Zn-SA/CNCl SAzyme by simultaneously constructing Zn-N₄ sites as catalytic sites and Zn-N₄Cl₁ sites as catalytic regulator. The Zn-N₄Cl₁ catalytic regulators effectively boost the peroxidase-like activities of Zn-N₄ catalytic sites, resulting in a 346-fold, 1496-fold, and 133-fold increase in the maximal reaction velocity, the catalytic constant and the catalytic efficiency, compared to Zn-SA/CN SAzyme without the Zn-N₄Cl₁ catalytic regulator. The Zn-SA/CNCl SAzyme with excellent peroxidase-like activity effectively inhibits tu

SUBMITTER: Wei S 

PROVIDER: S-EPMC11319669 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature