An immunoinformatics approach for design and validation of multi-subunit vaccine against <i>Plasmodium falciparum</i> from essential hypothetical proteins.

ABSTRACT: Malaria, caused by Plasmodium falciparum, remains a pressing global health concern. Advancements in combating this parasite involve the development of a protein vaccine. This study employs immunoinformatics to identify potential vaccine candidates within the repertoire of 218 P. falciparum exported essential proteins identified through saturaturation mutagenesis study. Our screening approach narrows down to 65 Plasmodium-exported proteins with uncharacterized functions while exhibiting non-mutability in CDS (coding sequences). The transmembrane helix, antigenicity, allergenicity of the shortlisted proteins was assessed through diverse prediction algorithm, culminating in the identification of five promising vaccination contenders, based on probability scores. We

SUBMITTER: Ritaparna P 

PROVIDER: S-EPMC11319695 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature