Correlation between serum advanced glycation end-products and vascular complications in patient with type 2 diabetes.

ABSTRACT: Advanced glycation end-products (AGEs) formation increases with metabolic disorders, leading to higher serum AGE levels in patients with progressive vascular complications. Measuring AGE levels in biological samples requires multiple pre-analytical processing steps, rendering analysis of multiple samples challenging. This study evaluated the progression of diabetic complications by analyzing AGE levels using a pre-analytical processing strategy based on a fully automated solid phase-extraction system. Serum samples from patients with diabetes, with or without macrovascular complications (Mac or non-Mac) or microvascular complications (Mic or non-Mic), were processed with the established methods. Free and total AGE levels in sera were measured using liquid chromatography coupled to tandem m

SUBMITTER: Kato S 

PROVIDER: S-EPMC11319737 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature