A Methodology for the Assessment and Prioritization of Genetic Biocontainment Technologies for Engineered Microbes.

ABSTRACT:

Introduction

Organisms engineered with synthetic genes and genomes have the potential to play critical roles to address important issues in the environment, human health, and manufacturing. Engineered genetic biocontainment technologies are needed to manage the risks of unintended consequences when deploying these biological systems in consultation with the biosafety and biosecurity communities. Metrics measuring genetic biocontainment and a methodology to apply them are required to determine which genetic biocontainment technologies warrant further development for real-world applications. In this study, we develop and apply a systems analysis of the current technical landscape using expert opinion and a metric-based scoring system resulting in a semiquantitative comparative assess

SUBMITTER: Payne S 

PROVIDER: S-EPMC11319856 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature