Cerebral Microbleeds in Different Brain Regions and Their Associations With the Digital Clock-Drawing Test: Secondary Analysis of the Framingham Heart Study.

ABSTRACT:

Background

Cerebral microbleeds (CMB) increase the risk for Alzheimer disease. Current neuroimaging methods that are used to detect CMB are costly and not always accessible.

Objective

This study aimed to explore whether the digital clock-drawing test (DCT) may provide a behavioral indicator of CMB.

Methods

In this study, we analyzed data from participants in the Framingham Heart Study offspring cohort who underwent both brain magnetic resonance imaging scans (Siemens 1.5T, Siemens Healthcare Private Limited; T2*-GRE weighted sequences) for CMB diagnosis and the DCT as a predictor. Additionally, paper-based clock-drawing tests were also collected during the DCT. Individuals with a history of dementia or stroke were excluded. Robust multivariable linear regression model

SUBMITTER: Akhter-Khan SC 

PROVIDER: S-EPMC11319892 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature