High-throughput ultrastructural analysis of macular telangiectasia type 2.

ABSTRACT:

Introduction

Macular Telangiectasia type 2 (MacTel), is an uncommon form of late-onset, slowly-progressive macular degeneration. Associated with regional Müller glial cell loss in the retina and the amino acid serine synthesized by Müller cells, the disease is functionally confined to a central retinal region - the MacTel zone.

Methods

We have used high-throughput multi-resolution electron microscopy techniques, optimized for disease analysis, to study the retinas from two women, mother and daughter, aged 79 and 48 years respectively, suffering from MacTel.

Results

In both eyes, the principal observations made were changes specific to mitochondrial structure both outside and within the MacTel zone in all retinal cell types, with the exception of those in the retinal p

SUBMITTER: Zucker CL 

PROVIDER: S-EPMC11319912 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature