A structure-redesigned intrinsically disordered peptide that selectively inhibits a plant transcription factor in jasmonate signaling.

ABSTRACT: Plant hormone-related transcription factors (TFs) are key regulators of plant development, responses to environmental stress such as climate changes, pathogens, and pests. These TFs often function as families that exhibit genetic redundancy in higher plants, and are affected by complex crosstalk mechanisms between different plant hormones. These properties make it difficult to analyze and control them in many cases. In this study, we introduced a chemical inhibitor to manipulate plant hormone-related TFs, focusing on the jasmonate (JA) and ethylene (ET) signaling pathways, with the key TFs MYC2/3/4 and EIN3/EIL1. This study revealed that JAZ10^CMID, the binding domain of the repressor involved in the desensitization of both TFs, is an intrinsically disordered region in the absenc

SUBMITTER: Takaoka Y 

PROVIDER: S-EPMC11319934 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature