TLK2 promotes progression of hepatocellular carcinoma through Wnt/β-catenin signaling.

ABSTRACT:

Background

Hepatocellular carcinoma is a widespread cancer worldwide, ranking as the fifth most frequent cancer and the fourth leading cause of cancer-related deaths. According to comprehensive research, TLK2, a phosphorylated kinase, has been discovered to play a crucial role in promoting tumor development. However, the prognostic significance and influence of TLK2 on hepatocellular carcinoma tumor cells and the immune microenvironment remain unexplored, warranting further investigation. The aim of this study was to investigate the role of TLK2 in promoting the development of hepatocellular carcinoma.

Methods

The present study utilized The Cancer Genome Atlas (TCGA) database and other databases as training sets to examine the expression of TLK2 a

SUBMITTER: He T 

PROVIDER: S-EPMC11319953 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature