Identification of a novel cellular senescence-related lncRNA signature for prognosis and immune response in osteosarcoma.

ABSTRACT:

Background

Cellular senescence, a novel hallmark of cancer, is associated with patient outcomes and tumor immunotherapy. However, at present, there is no systematic study on the use of cellular senescence-related long non-coding RNAs (CSR-lncRNAs) to predict survival in patients with osteosarcoma. In this study, we aimed to identify a CSR-lncRNAs signature and to evaluate its potential use as a survival prognostic marker and predictive tool for immune response of osteosarcoma.

Methods

We downloaded a cohort of patients with osteosarcoma from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. We performed differential expression and co-expression analyses to identify CSR-lncRNAs. We performed univariate and multivariate Cox regression analyses along w

SUBMITTER: Wu H 

PROVIDER: S-EPMC11319968 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature