Clinical research progress of telomerase targeted cancer immunotherapy: a literature review.

ABSTRACT:

Background and objective

Telomerase is activated or overexpressed in 85-90% of tumors, which maintains the length of telomere and has become an important anti-cancer target. Increasing clinical and preclinical data suggest that telomerase-targeted cancer immunotherapy could achieve effective killing of tumor cells in vivo. This article reviews the research progress of telomerase targeted cancer immunotherapy in clinical and pre-clinical trials, aiming to provide a reference for further clinical research and treatment of cancers.

Methods

We investigated the research progress of telomerase immunotherapy in the last 20 years from four electronic databases.

Key content and findings

Telomerase-targeted immunotherapies have been developed with the arising of a new er

SUBMITTER: Wang Y 

PROVIDER: S-EPMC11319969 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature