Bioinformatics reveals the potential mechanisms and biomarkers of necroptosis in neuroblastoma.

ABSTRACT:

Background

Neuroblastoma (NB) is a malignant tumor primarily found in children, presenting significant challenges in its development and prognosis. The role of necroptosis in the pathogenesis of NB has been acknowledged as crucial for treatment. This study aimed to investigate the key genes and functional pathways associated with necroptosis, as well as immune infiltration analysis, in NB. Furthermore, we aimed to evaluate the diagnostic significance of these genes for prognostic assessment and explore their potential immunological characteristics.

Methods

The NB dataset (GSE19274, GSE73517, and GSE85047) was obtained from the Gene Expression Omnibus (GEO) database, and genes associated with necroptosis were collected from GeneCards and previous literature. First, we conduct

SUBMITTER: Gao B 

PROVIDER: S-EPMC11319990 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature