Association between serum calcium levels and in-hospital mortality in sepsis: A retrospective cohort study.

ABSTRACT:

Background

This study examines serum calcium levels and in-hospital mortality in patients with sepsis, a subject with contradictory findings in the existing literature.

Methods

This retrospective cohort study utilized data from the MIMIC-IV database, focusing on adult patients diagnosed with sepsis between 2008 and 2019. The serum calcium levels were taken as the highest value within the first 24 h of Intensive Care Unit (ICU) admission. We performed Cox proportional hazards regression analyses in multivariable-adjusted models to investigate the association between serum calcium levels and in-hospital mortality. Restricted cubic spline functions were used to assess the nonlinear relationship, and threshold effect analysis was conducted to identify potential inflection points

SUBMITTER: Wang H 

PROVIDER: S-EPMC11320162 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature