Comparative Safety of In Utero Exposure to Buprenorphine Combined With Naloxone vs Buprenorphine Alone.

ABSTRACT:

Importance

Buprenorphine combined with naloxone is commonly used to treat opioid use disorders outside of pregnancy. In pregnancy, buprenorphine alone is generally recommended because of limited perinatal safety data on the combination product.

Objective

To compare perinatal outcomes following prenatal exposure to buprenorphine with naloxone vs buprenorphine alone.

Design, settings, and participants

Population-based cohort study using health care utilization data from Medicaid-insured beneficiaries in the US from 2000 to 2018. The cohort was restricted to pregnant individuals linked to their liveborn infants, with maternal Medicaid enrollment from 3 months before pregnancy to 1 month after delivery and infant enrollment for the first 3 months after birth, unless they

SUBMITTER: Straub L 

PROVIDER: S-EPMC11320336 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature