Unveiling ceramide dynamics: Shedding light on healthy aging in growth hormone-releasing hormone knockout mice.

ABSTRACT: Dysregulation of growth hormone (GH) signaling consistently leads to increased lifespan in laboratory rodents, yet the precise mechanisms driving this extension remain unclear. Understanding the molecular underpinnings of the beneficial effects associated with GH deficiency could unveil novel therapeutic targets for promoting healthy aging and longevity. In our pursuit of identifying metabolites implicated in aging, we conducted an unbiased lipidomic analysis of serum samples from growth hormone-releasing hormone knockout (GHRH-KO) female mice and their littermate controls. Employing a targeted lipidomic approach, we specifically investigated ceramide levels in GHRH-KO mice, a well-established model of enhanced longevity. While younger GHRH-KO mice did not exhibit notable differences in se

SUBMITTER: Lasher AT 

PROVIDER: S-EPMC11320351 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature