Age-related and species-specific methylation changes in the protein-coding marmoset sperm epigenome.

ABSTRACT: The sperm epigenome is thought to affect the developmental programming of the resulting embryo, influencing health and disease in later life. Age-related methylation changes in the sperm of old fathers may mediate the increased risks for reproductive and offspring medical problems. The impact of paternal age on sperm methylation has been extensively studied in humans and, to a lesser extent, in rodents and cattle. Here, we performed a comparative analysis of paternal age effects on protein-coding genes in the human and marmoset sperm methylomes. The marmoset has gained growing importance as a non-human primate model of aging and age-related diseases. Using reduced representation bisulfite sequencing, we identified age-related differentially methylated transcription start site (ageTSS) regi

SUBMITTER: Dittrich M 

PROVIDER: S-EPMC11320356 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature