Structure-function relationships in pure archaeal bipolar tetraether lipids.

ABSTRACT: Archaeal bipolar tetraether lipids (BTLs) are among the most unusual lipids occurring in nature because of their presumed ability to span the entire membrane to form a monolayer structure. It is believed that because of their unique structural organization and chemical stability, BTLs offer extraordinary adaptation to archaea to thrive in the most extreme milieus. BTLs have also received considerable attention for development of novel membrane-based materials. Despite their fundamental biological significance and biotechnological interests, prior studies on pure BTLs are limited because of the difficulty to extract them in pure form from natural sources or to synthesize them chemically. Here we have utilized chemical synthesis to enable in-depth biophysical investigations on a series of ch

SUBMITTER: Bhattacharya A 

PROVIDER: S-EPMC11320390 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature