¹⁸F-FDG PET can effectively rule out conversion to dementia and the presence of CSF biomarker of neurodegeneration: a real-world data analysis.

ABSTRACT:

Background

Precisely defining the delay in onset of dementia is a particular challenge for early diagnosis. Brain [¹⁸F] fluoro-2-deoxy-2-D-glucose (¹⁸F-FDG) Positron Emission Tomography (PET) is a particularly interesting tool for the early diagnosis of neurodegenerative diseases, through the measurement of the cerebral glucose metabolic rate. There is currently a lack of longitudinal studies under real-life conditions, with sufficient patients, to accurately evaluate the predictive values of brain ¹⁸F-FDG PET scans. Here, we aimed to estimate the value of brain ¹⁸F-FDG PET for predicting the risk of dementia conversion and the risk of occurrence of a neurodegenerative pathology.

Methods

Longitudinal data for a cohort of patients w

SUBMITTER: Heyer S 

PROVIDER: S-EPMC11320856 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature