Vitamin B12 status and the risk of developing sepsis in patients with bacterial infection: a prospective observational cohort study.

ABSTRACT:

Background

Data have shown that vitamin B12 has immunomodulatory effects via different pathways, which could influence the pathophysiology of sepsis. The objective of this study was to investigate whether vitamin B12 levels, assessed by the measurement of holotranscobalamin (HTC), total vitamin B12 (B12), and methylmalonic acid (MMA, which accumulates in case of B12 deficiency), are associated with the development of sepsis in patients with onset of bacterial infection.

Methods

This was a single-center, prospective observational pilot study. Adult patients who presented to the emergency department with bacterial infection confirmed by a positive microbiological culture result were included in the study and followed up for 6 days to assess whether they developed sepsis or not

SUBMITTER: Pregernig A 

PROVIDER: S-EPMC11320857 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature