Prevalence of and gene regulatory constraints on transcriptional adaptation in single cells.

ABSTRACT:

Background

Cells and tissues have a remarkable ability to adapt to genetic perturbations via a variety of molecular mechanisms. Nonsense-induced transcriptional compensation, a form of transcriptional adaptation, has recently emerged as one such mechanism, in which nonsense mutations in a gene trigger upregulation of related genes, possibly conferring robustness at cellular and organismal levels. However, beyond a handful of developmental contexts and curated sets of genes, no comprehensive genome-wide investigation of this behavior has been undertaken for mammalian cell types and conditions. How the regulatory-level effects of inherently stochastic compensatory gene networks contribute to phenotypic penetrance in single cells remains unclear.

Results

We analyze existing bul

SUBMITTER: Mellis IA 

PROVIDER: S-EPMC11320884 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature