Echinococcus multilocularis serpin regulates macrophage polarization and reduces gut dysbiosis in colitis.

ABSTRACT: Helminths serve as principal regulators in modulating host immune responses, and their excretory-secretory proteins are recognized as potential therapeutic agents for inflammatory bowel disease. Nevertheless, our comprehension of the mechanisms underlying immunoregulation remains restricted. This investigation delves into the immunomodulatory role of a secretory protein serpin (Emu-serpin), within the larval stage of Echinococcus multilocularis. Our observations indicate that Emu-serpin effectively alleviates dextran sulfate sodium-induced colitis, yielding a substantial reduction in immunopathology and an augmentation of anti-inflammatory cytokines. Furthermore, this suppressive regulatory effect is concomitant with the reduction of gut microbiota dysbiosis linked to

SUBMITTER: Li X 

PROVIDER: S-EPMC11320943 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature