Insomnia and sleep duration for kidney function: Mendelian randomization study.

ABSTRACT:

Objectives

Extensive researches highlight the detrimental impact of sleep disorders such as insomnia and insufficient sleep duration on kidney function. However, establishing a clear causal relationship between insomnia, sleep duration, and kidney function remains challenging. This study aims to estimate this relationship using Mendelian randomization (MR).

Methods

Independent genetic variants strongly associated with insomnia (N = 462,341) and sleep duration (N = 460,099) were selected as instrumental variables from corresponding genome-wide association studies (GWAS). Kidney function parameters, including serum creatinine, estimated glomerular filtration rate by cystatin C (eGFRcys), acute renal failure (ARF), chronic renal failure (CRF), kidney injury molecu

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC11321106 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature