Redefining urine output thresholds for acute kidney injury criteria in critically Ill patients: a derivation and validation study.

ABSTRACT:

Introduction

The current definition of acute kidney injury (AKI) includes increased serum creatinine (sCr) concentration and decreased urinary output (UO). Recent studies suggest that the standard UO threshold of 0.5 ml/kg/h may be suboptimal. This study aimed to develop and validate a novel UO-based AKI classification system that improves mortality prediction and patient stratification.

Methods

Data were obtained from the MIMIC-IV and eICU databases. The development process included (1) evaluating UO as a continuous variable over 3-, 6-, 12-, and 24-h periods; (2) identifying 3 optimal UO cutoff points for each time window (stages 1, 2, and 3); (3) comparing sensitivity and specificity to develop a unified staging system; (4) assessing average versus persistent reduced UO h

SUBMITTER: Machado GD 

PROVIDER: S-EPMC11321122 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature