Causality between migraine and cardiovascular disease: a bidirectional Mendelian randomization study.

ABSTRACT:

Background

While growing evidence suggests a relationship between migraine and cardiovascular disease, the genetic evidence for a causal relationship between migraine and cardiovascular disease is still scarce. Investigating the causal association between migraine and cardiovascular disease is vital.

Methods

We carried out a bidirectional Mendelian randomization (MR) study including discovery samples and replication samples using publicly available genome-wide association study (GWAS) summary datasets and stringent screening instrumental variables. Four different MR techniques-Inverse variance weighted (IVW), MR ‒Egger, weighted median, and weighted mode-as well as various sensitivity analyses-Cochran's Q, IVW radial, leave-one-out (LOO), and MR-PRESSO-were utilized to inves

SUBMITTER: Duan X 

PROVIDER: S-EPMC11321219 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature