Daytime napping and the incidence of Parkinson's disease: a prospective cohort study with Mendelian randomization.

ABSTRACT:

Background

The causal relationship between daytime napping and the risk of Parkinson's disease (PD) remains unclear, with prospective studies providing limited evidence. This study investigated the association between daytime napping frequency and duration and PD incidence and explored the causality relationship between this association by conducting Mendelian randomization (MR) analysis.

Methods

This prospective cohort study included 393,302 participants, and accelerometer-measured daytime napping data were available only for 78,141 individuals. Cox proportional hazards regression was used to estimate the association between the daytime napping frequency and duration and the PD risk. The role of the systemic immune-inflammation index (SII) in the association between daytime

SUBMITTER: Lin F 

PROVIDER: S-EPMC11321229 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature