Baicalin reduces chronic stress-induced breast cancer metastasis via directly targeting β2-adrenergic receptor.

ABSTRACT: Recent studies have shown that stress can substantially facilitate breast cancer metastasis, which can be reduced by nonselective β1/β2-adrenergic receptor (β1/β2-AR) blocker. However, several side effects were identified. Thus, it is extremely warranted to explore more effective and better-tolerated β2-AR blocker. Currently, we demonstrated that baicalin (BA), a major bioactive component of Scutellaria baicalensis Georgi, could significantly attenuate stress hormones especially epinephrine (Epi)-induced breast cancer cell migration and invasion in vitro. Mechanistically, we identified that β2-AR was a direct target of BA via the drug affinity responsive target stability (DARTS) combined with mass spectrum assay, and BA photoaffinity probe with pull-down assay, which was furt

SUBMITTER: Jia Q 

PROVIDER: S-EPMC11321295 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature