Metabolomics biomarkers of hepatocellular carcinoma in a prospective cohort of patients with cirrhosis.

ABSTRACT:

Background & aims

The effectiveness of surveillance for hepatocellular carcinoma (HCC) in patients with cirrhosis is limited, due to inadequate risk stratification and suboptimal performance of current screening modalities.

Methods

We developed a multicenter prospective cohort of patients with cirrhosis undergoing surveillance with MRI and applied global untargeted metabolomics to 612 longitudinal serum samples from 203 patients. Among them, 37 developed HCC during follow-up.

Results

We identified 150 metabolites with significant abundance changes in samples collected prior to HCC (Cases) compared to samples from patients who did not develop HCC (Controls). Tauro-conjugated bile acids and gamma-glutamyl amino acids were increased, while acyl-cholines and deoxycholate

SUBMITTER: Sanchez JI 

PROVIDER: S-EPMC11321296 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature