Deep PIM kinase substrate profiling reveals new rational cotherapeutic strategies for acute myeloid leukemia.

ABSTRACT:

Abstract

Provirus integration site for Moloney murine leukemia virus (PIM) family serine/threonine kinases perform protumorigenic functions in hematologic malignancies and solid tumors by phosphorylating substrates involved in tumor metabolism, cell survival, metastasis, inflammation, and immune cell invasion. However, a comprehensive understanding of PIM kinase functions is currently lacking. Multiple small-molecule PIM kinase inhibitors are currently being evaluated as cotherapeutics in patients with cancer. To further illuminate PIM kinase functions in cancer, we deeply profiled PIM1 substrates using the reverse in-gel kinase assay to identify downstream cellular processes targetable with small molecules. Pathway analyses of putative PIM substrates nominated RNA splicing and rib

SUBMITTER: Joglekar T 

PROVIDER: S-EPMC11321302 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature