Metastatic breast cancer cells are metabolically reprogrammed to maintain redox homeostasis during metastasis.

ABSTRACT: Metabolic rewiring is essential for tumor growth and progression to metastatic disease, yet little is known regarding how cancer cells modify their acquired metabolic programs in response to different metastatic microenvironments. We have previously shown that liver-metastatic breast cancer cells adopt an intrinsic metabolic program characterized by increased HIF-1α activity and dependence on glycolysis. Here, we confirm by in vivo stable isotope tracing analysis (SITA) that liver-metastatic breast cancer cells retain a glycolytic profile when grown as mammary tumors or liver metastases. However, hepatic metastases exhibit unique metabolic adaptations including elevated expression of genes involved in glutathione (GSH) biosynthesis and reactive oxygen species (ROS) detoxification when comp

SUBMITTER: Biondini M 

PROVIDER: S-EPMC11321393 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature