Critical factors for precise and efficient RNA cleavage by RNase Y in Staphylococcus aureus.

ABSTRACT: Cellular processes require precise and specific gene regulation, in which continuous mRNA degradation is a major element. The mRNA degradation mechanisms should be able to degrade a wide range of different RNA substrates with high efficiency, but should at the same time be limited, to avoid killing the cell by elimination of all cellular RNA. RNase Y is a major endoribonuclease found in most Firmicutes, including Bacillus subtilis and Staphylococcus aureus. However, the molecular interactions that direct RNase Y to cleave the correct RNA molecules at the correct position remain unknown. In this work we have identified transcripts that are homologs in S. aureus and B. subtilis, and are RNase Y targets in both bacteria. Two such transcript pairs were used as models to show a functional overl

SUBMITTER: Le Scornet A 

PROVIDER: S-EPMC11321564 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature