Oral resveratrol in adults with knee osteoarthritis: A randomized placebo-controlled trial (ARTHROL).

ABSTRACT:

Background

Resveratrol is a natural compound found in red wine. It has demonstrated anti-inflammatory properties in preclinical models. We compared the effect of oral resveratrol in a new patented formulation to oral placebo for individuals with painful knee osteoarthritis.

Methods and findings

ARTHROL was a double-blind, randomized, placebo-controlled, Phase 3 trial conducted in 3 tertiary care centers in France. We recruited adults who fulfilled the 1986 American College of Rheumatology criteria for knee osteoarthritis and reported a pain intensity score of at least 40 on an 11-point numeric rating scale (NRS) in 10-point increments (0, no pain, to 100, maximal pain). Participants were randomly assigned (1:1) by using a computer-generated randomization list with permuted b

SUBMITTER: Nguyen C 

PROVIDER: S-EPMC11321588 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature