In Silico Screening Accelerates Nanocarrier Design for Efficient mRNA Delivery.

ABSTRACT: Lipidic nanocarriers are a broad class of lipid-based vectors with proven potential for packaging and delivering emerging nucleic acid therapeutics. An important early step in the clinical development cycle is large-scale screening of diverse formulation libraries to assess particle quality and payload delivery efficiency. Due to the size of the screening space, this process can be both costly and time-consuming. To address this, computational models capable of predicting clinically relevant physio-chemical properties of dendrimer-lipid nanocarriers, along with their mRNA payload delivery efficiency in human cells are developed. The models are then deployed on a large theoretical nanocarrier pool consisting of over 4.5 million formulations. Top predictions are synthesised for validation us

SUBMITTER: Henser-Brownhill T 

PROVIDER: S-EPMC11321627 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature