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Integrated Single-Cell RNA-seq and ATAC-seq Reveals Heterogeneous Differentiation of CD4⁺ Naive T Cell Subsets is Associated with Response to Antidepressant Treatment in Major Depressive Disorder.

ABSTRACT: The mechanism involved in major depressive disorder (MDD) is well-studied but the mechanistic origin of the heterogeneous antidepressant effect remains largely unknown. Single-cell RNA-sequencing (scRNA-seq) and assay for transposase-accessible chromatin using sequencing (ATAC-seq) on peripheral blood mononuclear cells from 8 healthy individuals and 8 MDD patients before or after 12 weeks of antidepressant treatment is performed. scRNA-seq analysis reveals a lower proportion of naive T cells, particularly CD4⁺ naive T cells, in MDD patients compared to controls, and in nonresponders versus responders at the baseline. Flow cytometry data analysis of an independent cohort of 35 patients and 40 healthy individuals confirms the findings. Enrichment analysis of differentially express

SUBMITTER: Sun Z

PROVIDER: S-EPMC11321657 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature

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Dataset Information

Integrated Single-Cell RNA-seq and ATAC-seq Reveals Heterogeneous Differentiation of CD4⁺ Naive T Cell Subsets is Associated with Response to Antidepressant Treatment in Major Depressive Disorder.

OmicsDI is part of the ELIXIR infrastructure

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Dataset Information

Integrated Single-Cell RNA-seq and ATAC-seq Reveals Heterogeneous Differentiation of CD4+ Naive T Cell Subsets is Associated with Response to Antidepressant Treatment in Major Depressive Disorder.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Integrated Single-Cell RNA-seq and ATAC-seq Reveals Heterogeneous Differentiation of CD4⁺ Naive T Cell Subsets is Associated with Response to Antidepressant Treatment in Major Depressive Disorder.