Psychiatric polygenic risk scores: Experience, hope for utility, and concerns among child and adolescent psychiatrists.

ABSTRACT: Recent advances in psychiatric genetics have enabled the use of polygenic risk scores (PRS) to estimate genetic risk for psychiatric disorders. However, the potential use of PRS in child and adolescent psychiatry has raised concerns. This study provides an in-depth examination of attitudes among child and adolescent psychiatrists (CAP) regarding the use of PRS in psychiatry. We conducted semi-structured interviews with U.S.-based CAP (n = 29) who possess expertise in genetics. The majority of CAP indicated that PRS have limited clinical utility in their current form and are not ready for clinical implementation. Most clinicians stated that nothing would motivate them to generate PRS at present; however, some exceptions were noted (e.g., parent/family request). Clinicians spoke to challenge

SUBMITTER: Merner AR 

PROVIDER: S-EPMC11321910 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature