Exercise-downregulated CD300E acted as a negative prognostic implication and tumor-promoted role in pan-cancer.

ABSTRACT:

Background

Breast cancer ranks as one of the most prevalent malignancies among women globally, with increasing incidence rates. Physical activity, particularly exercise, has emerged as a potentially significant modifier of cancer prognosis, influencing tumor biology and patient outcomes.

Methods

Using a murine breast cancer model, we established a control and an exercise group, where the latter was subjected to 21 days of voluntary running. RNA Sequencing, bioinformatics analysis, pan-cancer analysis, and cell experiments were performed to validate the underlying mechanisms.

Results

We observed that exercise significantly reduced tumor size and weight, without notable changes in body weight, suggesting that physical activity can modulate tumor dynamics. mRNA sequencin

SUBMITTER: Luo Z 

PROVIDER: S-EPMC11321962 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature