Striatal GABA levels correlate with risk sensitivity in monetary loss.

ABSTRACT:

Background

Decision-making under risk is a common challenge. It is known that risk-taking behavior varies between contexts of reward and punishment, yet the mechanisms underlying this asymmetry in risk sensitivity remain unclear.

Methods

This study used a monetary task to investigate neurochemical mechanisms and brain dynamics underpinning risk sensitivity. Twenty-eight participants engaged in a task requiring selection of visual stimuli to maximize monetary gains and minimize monetary losses. We modeled participant trial-and-error processes using reinforcement learning.

Results

Participants with higher subjective utility parameters showed risk preference in the gain domain (r = -0.59) and risk avoidance in the loss domain (r = -0.77). Magnetic resonance

SUBMITTER: Kondo HM 

PROVIDER: S-EPMC11321969 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature