Toxin-antitoxin system gene mutations driving Mycobacterium tuberculosis transmission revealed by whole genome sequencing.

ABSTRACT:

Background

The toxin-antitoxin (TA) system plays a vital role in the virulence and pathogenicity of Mycobacterium tuberculosis (M. tuberculosis). However, the regulatory mechanisms and the impact of gene mutations on M. tuberculosis transmission remain poorly understood.

Objective

To investigate the influence of gene mutations in the toxin-antitoxin system on M. tuberculosis transmission dynamics.

Method

We performed whole-genome sequencing on the analyzed strains of M. tuberculosis. The genes associated with the toxin-antitoxin system were obtained from the National Center for Biotechnology Information (NCBI) Gene database. Mutations correlating with enhanced transmission within the genes were identified by using random forest, grad

SUBMITTER: Hou Y 

PROVIDER: S-EPMC11322068 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature