Effect modification by sex of genetic associations of vitamin C related metabolites in the Canadian Longitudinal study on aging.

ABSTRACT: Introduction: Vitamin C is an essential nutrient. Sex differences in serum vitamin C concentrations have been observed but are not fully known. Investigation of levels of metabolites may help shed light on how dietary and other environmental exposures interact with molecular processes. O-methylascorbate and ascorbic acid 2-sulfate are two metabolites in the vitamin C metabolic pathway. Past research has found genetic factors that influence the levels of these two metabolites. Therefore, we investigated possible effect modification by sex of genetic variant-metabolite associations and characterized the biological function of these interactions. Methods: We included individuals of European descent from the Canadian Longitudinal Study on Aging with available genetic and metaboli

SUBMITTER: Lelievre R 

PROVIDER: S-EPMC11322087 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature