Comparable cognitive impairment was detected in MACS and CS and alleviated after remission of hypercortisolism in MACS.

ABSTRACT:

Context

Few studies have directly compared the cognitive characteristics of patients with mild autonomous cortisol secretion (MACS) and Cushing's syndrome (CS). The effect of surgical or conservative treatment on cognitive function in patients with MACS is still unclear.

Objective

To compare the differences in cognitive function between patients with MACS and CS and evaluate the effect of surgery or conservative treatment on cognitive function.

Methods

We prospectively recruited 59 patients with nonfunctional adrenal adenoma (NFA), 36 patients with MACS, and 20 patients with adrenal CS who completed the global cognition and cognitive subdomains assessments. Seventeen MACS patients were re-evaluated for cognitive function after a 12-month follow-up period; of these, el

SUBMITTER: Liu M 

PROVIDER: S-EPMC11322108 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature