Genetic and causal relationship between chronic gastrointestinal diseases and erectile dysfunction: a Mendelian randomization study.

ABSTRACT:

Background

Studies based on observations have indicated potential associations between chronic gastrointestinal diseases and an increased risk of erectile dysfunction (ED). However, the causality of these connections remains ambiguous.

Methods

Summary data for chronic gastrointestinal diseases were extracted from public data. Summary data on ED were extracted from three distinct sources. The genetic correlations between chronic gastrointestinal diseases and ED were explored using linkage disequilibrium score regression (LDSC). The causal associations between chronic gastrointestinal diseases and ED were evaluated using Mendelian randomization (MR) analysis, followed by a meta-analysis to determine the ultimate causal effect.

Results

The LDSC results suggested signific

SUBMITTER: Zeng X 

PROVIDER: S-EPMC11322132 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature