A neuronal circuit driven by GLP-1 in the olfactory bulb regulates insulin secretion.

ABSTRACT: Glucagon-like peptide 1 (GLP-1) stimulates insulin secretion and holds significant pharmacological potential. Nevertheless, the regulation of energy homeostasis by centrally-produced GLP-1 remains partially understood. Preproglucagon cells, known to release GLP-1, are found in the olfactory bulb (OB). We show that activating GLP-1 receptors (GLP-1R) in the OB stimulates insulin secretion in response to oral glucose in lean and diet-induced obese male mice. This is associated with reduced noradrenaline content in the pancreas and blocked by an α₂-adrenergic receptor agonist, implicating functional involvement of the sympathetic nervous system (SNS). Inhibiting GABA_A receptors in the paraventricular nucleus of the hypothalamus (PVN), the control centre of the SNS, aboli

SUBMITTER: Montaner M 

PROVIDER: S-EPMC11322178 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature