Exploring the crosstalk molecular mechanisms between IgA nephropathy and Sjogren's syndrome based on comprehensive bioinformatics and immunohistochemical analyses.

ABSTRACT: IgA nephropathy (IgAN) and Sjogren's syndrome (SS) are two autoimmune diseases with undetermined etiology and related to abnormal activation of lymphocytes. This study aims to explore the crucial genes, pathways and immune cells between IgAN and SS. Gene expression profiles of IgAN and SS were obtained from the Gene Expression Omnibus and Nephroseq data. Differentially expressed gene (DEG) and weighted gene co-expression network analyses (WGCNA) were done to identify common genes. Enrichment analysis and protein-protein interaction network were used to explore potential molecular pathways and crosstalk genes between IgAN and SS. The results were further verified by external validation and immunohistochemistry (IHC) analysis. Additionally, immune cell analysis and transcription factor predi

SUBMITTER: He P 

PROVIDER: S-EPMC11322200 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature