Association between cathepsins and skin cancers: A bidirectional two-sample Mendelian randomization study.

ABSTRACT:

Background

Several cathepsins have been identified as being involved in the development of cancer. Nevertheless, the connection between cathepsins and skin cancers remained highly elusive.

Methods

A bidirectional Mendelian randomization (MR) analysis was performed to investigate the causal association between cathepsins and skin malignancies. The genome-wide association studies (GWAS) data for cathepsins, malignant melanoma (MM), and basal cell carcinoma (BCC) were obtained from European research. The primary method employed was inverse variance weighted. In addition, MR-Egger, weighted median, weighted mode, and simple mode were also executed. Sensitivity analysis was performed using Cochran's Q test, MR-Egger, and MR-PRESSO.

Results

From univariable MR (UVMR), cathe

SUBMITTER: Ma X 

PROVIDER: S-EPMC11322223 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature