The prognostic effect of tumor-associated macrophages in stage I-III colorectal cancer depends on T cell infiltration.

ABSTRACT:

Background

Tumor-associated macrophages (TAMs) are associated with unfavorable patient prognosis in many cancer types. However, TAMs are a heterogeneous cell population and subsets have been shown to activate tumor-infiltrating T cells and confer a good patient prognosis. Data on the prognostic value of TAMs in colorectal cancer are conflicting. We investigated the prognostic effect of TAMs in relation to tumor-infiltrating T cells in colorectal cancers.

Methods

The TAM markers CD68 and CD163 were analyzed by multiplex fluorescence immunohistochemistry and digital image analysis on tissue microarrays of 1720 primary colorectal cancers. TAM density in the tumor stroma was scored in relation to T cell density (stromal CD3⁺ and epithelial CD8⁺ cells) and a

SUBMITTER: Majid U 

PROVIDER: S-EPMC11322253 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature