Multi-dimensional characterization of apoptosis in the tumor microenvironment and therapeutic relevance in melanoma.

ABSTRACT:

Purpose

Melanoma is widely utilized as a prominent model for the development of immunotherapy, thought an inadequate immune response can occur. Moreover, the development of apoptosis-related therapies and combinations with other therapeutic strategies is impeded by the limited understanding of apoptosis's role within diverse tumor immune microenvironments (TMEs).

Methods

Here, we constructed an apoptosis-related tumor microenvironment signature (ATM) and employ multi-dimensional analysis to understand the roles of apoptosis in tumor microenvironment. We further assessed the clinical applications of ATM in nine independent cohorts, and anticipated the impact of ATM on cellular drug response in cultured cells.

Results

Our ATM model exhibits robust performance in surviva

SUBMITTER: Ye J 

PROVIDER: S-EPMC11322377 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature