Exploring white matter dynamics and morphology through interactive numerical phantoms: the White Matter Generator.

ABSTRACT: Brain white matter is a dynamic environment that continuously adapts and reorganizes in response to stimuli and pathological changes. Glial cells, especially, play a key role in tissue repair, inflammation modulation, and neural recovery. The movements of glial cells and changes in their concentrations can influence the surrounding axon morphology. We introduce the White Matter Generator (WMG) tool to enable the study of how axon morphology is influenced through such dynamical processes, and how this, in turn, influences the diffusion-weighted MRI signal. This is made possible by allowing interactive changes to the configuration of the phantom generation throughout the optimization process. The phantoms can consist of myelinated axons, unmyelinated axons, and cell clusters, separated by ex

SUBMITTER: Winther S 

PROVIDER: S-EPMC11322502 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature