Altering traits and fates of wild populations with Mendelian DNA sequence modifying Allele Sails.

ABSTRACT: Population-scale genome modification can alter the composition or fate of wild populations. Synthetic gene drives provide one set of tools, but their use is complicated by scientific, regulatory, and social issues associated with transgene persistence and flow. Here we propose an alternative approach. An Allele Sail consists of a genome editor (the Wind) that introduces DNA sequence edits, and is inherited in a Mendelian fashion. Meanwhile, the edits (the Sail) experience an arithmetic, Super-Mendelian increase in frequency. We model this system and identify contexts in which a single, low frequency release of an editor brings edits to a very high frequency. We also identify conditions in which manipulation of sex determination can bring about population suppression. In regulatory framewor

SUBMITTER: Johnson ML 

PROVIDER: S-EPMC11322531 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature