Fucoidan improving spinal cord injury recovery: Modulating microenvironment and promoting remyelination.

ABSTRACT:

Introduction

Excessive neuroinflammation, apoptosis, glial scar, and demyelination triggered by spinal cord injury (SCI) are major obstacles to SCI repair. Fucoidan, a natural marine plant extract, possesses broad-spectrum anti-inflammatory and immunomodulatory effects and is regarded as a potential therapeutic for various diseases, including neurological disorders. However, its role in SCI has not been investigated.

Methods

In this study, we established an SCI model in mice and intervened in injury repair by daily intraperitoneal injections of different doses of fucoidan (10 and 20 mg/kg). Concurrently, primary oligodendrocyte precursor cells (OPCs) were treated in vitro to validate the differentiation-promoting effect of fucoidan on OPCs. Basso Mouse Scale (BMS), Louisvill

SUBMITTER: Shu H 

PROVIDER: S-EPMC11322593 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature